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Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
Xylitol is poisonous to dogs. [8] Ingesting 100 milligrams of xylitol per kilogram of body weight (mg/kg bw) causes dogs to experience a dose-dependent insulin release; depending on the dose it can result in life-threatening hypoglycemia. Hypoglycemic symptoms of xylitol toxicity may arise as quickly as 30 to 60 minutes after ingestion.
It may be drug-induced, for example in cats and dogs by acetaminophen (paracetamol), [84] or may be caused by eating various plants or other substances: In cats and dogs after eating either raw or cooked plants from the genus Allium , for example, onions or garlic.
ADRs associated with the use of intravenous lidocaine are similar to the toxic effects of systemic exposure above. These are dose-related and more frequent at high infusion rates (≥3 mg/min). Common ADRs include headache, dizziness, drowsiness, confusion, visual disturbances, tinnitus, tremor, and/or paraesthesia.
Immature maize shoots accumulate a powerful antibiotic substance, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one , which provides a measure of protection against a wide range of pests. [36] Because of its shallow roots, maize is susceptible to droughts, intolerant of nutrient-deficient soils, and prone to being uprooted by severe winds. [37]
Sample of human urine. Urine is a liquid by-product of metabolism in humans and in many other animals. In placental mammals, urine flows from the kidneys through the ureters to the urinary bladder and exits the urethra through the penis or vulva during urination.