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Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
A lower dose may be required in those with liver problems. [7] It is generally safe to use in those allergic to tetracaine or benzocaine. [8] Lidocaine is an antiarrhythmic medication of the class Ib type. [7] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart.
Xylitol is poisonous to dogs. [8] Ingesting 100 milligrams of xylitol per kilogram of body weight (mg/kg bw) causes dogs to experience a dose-dependent insulin release; depending on the dose it can result in life-threatening hypoglycemia. Hypoglycemic symptoms of xylitol toxicity may arise as quickly as 30 to 60 minutes after ingestion.
In human blood plasma, the reference range of uric acid is typically 3.4–7.2 mg per 100 mL(200–430 μmol/L) for men, and 2.4–6.1 mg per 100 mL for women (140–360 μmol/L). [34] Uric acid concentrations in blood plasma above and below the normal range are known as, respectively, hyperuricemia and hypouricemia .
Immature maize shoots accumulate a powerful antibiotic substance, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one , which provides a measure of protection against a wide range of pests. [36] Because of its shallow roots, maize is susceptible to droughts, intolerant of nutrient-deficient soils, and prone to being uprooted by severe winds. [37]
The sugar added to meat for the purpose of curing it comes in many forms, including honey, corn syrup solids, and maple syrup. [14] However, with the exception of bacon, it does not contribute much to the flavor, [ 15 ] but it does alleviate the harsh flavor of the salt. [ 11 ]
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