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  2. Erythromelalgia - Wikipedia

    en.wikipedia.org/wiki/Erythromelalgia

    For secondary erythromelalgia, treatment of the underlying primary disorder is the most primary method of treatment. Although aspirin has been thought to reduce symptoms of erythromelalgia, it is rare to find evidence that this is effective. Mechanical cooling of the limbs by elevating them can help or managing the ambient environment ...

  3. Paroxysmal extreme pain disorder - Wikipedia

    en.wikipedia.org/wiki/Paroxysmal_extreme_pain...

    PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel Na V 1.7 encoded by the gene SCN9A .

  4. Polycythemia vera - Wikipedia

    en.wikipedia.org/wiki/Polycythemia_vera

    Erythromelalgia is a rare symptom of PV, here present in a patient with longstanding polycythemia vera. Note reddish limbs and swelling. People with polycythemia vera can be asymptomatic. [4] Clinical symptoms of polycythemia vera are mostly due to hyperviscosity of blood.

  5. Blood vessel disorder - Wikipedia

    en.wikipedia.org/wiki/Blood_vessel_disorder

    Erythromelalgia is a rare clinical disorder causing redness, burning sensation and intense pain in limbs. [12] It is more common to be found in lower limbs than upper limbs. [ 12 ] Erythromelalgia initiated from dysfunction of peripheral nerves that thickens the blood vessel walls, resulting in hyperaemic flow in limbs.

  6. TMEM8B - Wikipedia

    en.wikipedia.org/wiki/TMEM8B

    Mutations with this gene can be pathogenic, and cause chronic pain disorders, specifically erythromelalgia symptoms. [5] [17] [18] Erythromelalgia is a rare condition that affects the extremities (hands and feet), and is characterized by intense, burning pain, severe redness, and increased skin temperature. [19] Medications are available to ...

  7. Silas Weir Mitchell (physician) - Wikipedia

    en.wikipedia.org/wiki/Silas_Weir_Mitchell...

    Mitchell's disease (erythromelalgia) is named after him. He also coined the term phantom limb during his study of an amputee. [6] Mitchell discovered and treated causalgia (today known as CRPS/RSD), a condition most often encountered by hand surgeons. Mitchell is considered the father of medical neurology and a pioneer of "evidence-based" or ...

  8. Complex regional pain syndrome - Wikipedia

    en.wikipedia.org/wiki/Complex_regional_pain_syndrome

    Complex regional pain syndrome (CRPS Type 1 and Type 2), sometimes referred to by the hyponyms Reflex Sympathetic Dystrophy (RSD) or Reflex Neurovascular Dystrophy (RND), is a rare and severe form of neuroinflammatory and dysautonomic disorder causing chronic pain, neurovascular, and neuropathic symptoms.

  9. Paralepistopsis amoenolens - Wikipedia

    en.wikipedia.org/wiki/Paralepistopsis_amoenolens

    The resulting syndrome of fungus-induced erythromelalgia lasted from 8 days to 5 months, although one person exhibited symptoms for three years. [8] This species contains acromelic acids including Acromelic acid A which is a potent neurotoxin with a chemical formula of C 13 H 14 N 2 O 7 and is associated with causing paralysis and seizures [9]