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Most Pax genes contain a homeobox and a paired domain that also binds DNA to increase binding specificity, though some Pax genes have lost all or part of the homeobox sequence. [46] Pax genes function in embryo segmentation, nervous system development, generation of the frontal eye fields, skeletal development, and formation of face structures.
IRX1 is a member of the Iroquois homeobox gene family. Members of this family play multiple roles during pattern formation in embryos of numerous vertebrate and invertebrate species. [5] [12] IRO genes are thought to function early in development to define large territories, and again later in development for further patterning specification. [7]
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [6]
IRX3 is a member of the Iroquois homeobox gene family and plays a role in an early step of neural development. [8] Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
The Lim gene family is a subfamily of homeobox genes. [7] The homeobox genes are essential in organizing the body plan of an organism and all contain the same conserved homeodomain of amino acids. [8] Evidence that Lim-1 is essential to a developing organism is its conservation throughout evolution and presence in a variety of organisms. [7]
Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene. [5] [6] [7] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene ...
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene. [ 5 ] [ 6 ] This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene. [5] [6] [7] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene ...