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1-Bromoadamantane is the organobromine compound with the formula (CH 2) 6 (CH) 3 CBr. A colorless solid, the compound is a derivative of adamantane with a bromine atom at one of the four equivalent methine positions.
The nuclear magnetic resonance (NMR) spectrum of adamantane consists of two poorly resolved signals, which correspond to sites 1 and 2 (see picture below). The 1 H and 13 C NMR chemical shifts are respectively 1.873 and 1.756 ppm and are 28.46 and 37.85 ppm. [28] The simplicity of these spectra is consistent with high molecular symmetry.
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Researchers discovered that amantadine and memantine bind to and act as agonists of the σ 1 receptor (K i = 7.44 μM and 2.60 μM, respectively) and that activation of the σ 1 receptor is involved in the central dopaminergic effects of amantadine at therapeutically relevant concentrations; the authors of the study stated that this could also ...
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