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Linaclotide, (sold under the brand name Linzess in the US and Mexico, and as Constella elsewhere) [6] is a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause.
Lubiprostone is a laxative used for the treatment of constipation, specifically: [9] Chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by diet, disease, or drugs).
Ironwood Pharmaceuticals Provides Third Quarter 2012 Investor Update - Received FDA Approval of LINZESS™ (linaclotide) for Treatment of Adult Patients with IBS-C or CIC; Prepared for Commercial ...
As plecanatide acts on receptors present on the apical side of endothelial cells lining the gastrointestinal tract it is able to impart its effect without ever entering circulation. [13] As with most orally ingested peptides, plecanatide is degraded by intestinal enzymes, and so very little of the active drug enters systemic circulation. [ 12 ]
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They said that 21 million doses of Librela have been given out and the side effects have been minimal. So far the F.D.A. has brought their findings to attention of veterinarians and is now ...
QT prolongation is an established side effect of antiarrhythmics, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antidepressants, antihistamines, opioids, and complementary medicines.
Dangerous side effects from the injectable canine drug Librela — used to treat osteoarthritis joint pain — have been linked to seizures, lameness and loss of muscle control, the FDA warned.