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Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, [6] IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes.
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
54139 Ensembl ENSG00000117595 ENSMUSG00000026638 UniProt O14896 P97431 RefSeq (mRNA) NM_006147 NM_001206696 NM_016851 NM_178083 RefSeq (protein) NP_001193625 NP_006138 NP_058547 Location (UCSC) Chr 1: 209.79 – 209.81 Mb Chr 1: 192.84 – 192.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by ...
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. [5] The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.
16391 Ensembl ENSG00000213928 ENSG00000285048 ENSMUSG00000002325 UniProt Q00978 Q61179 RefSeq (mRNA) NM_006084 NM_001385400 NM_001385401 NM_001385402 NM_001159417 NM_001159418 NM_008394 RefSeq (protein) NP_006075 NP_001152889 NP_001152890 NP_032420 Location (UCSC) Chr 14: 24.16 – 24.17 Mb Chr 14: 55.84 – 55.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory ...
Download as PDF; Printable version ... 1957 naming the antiviral factor they had discovered interferon. ... as immune interferon and is activated by Interleukin-12. [3]
270110 Ensembl ENSG00000168264 ENSMUSG00000051495 UniProt Q7Z5L9 E9Q1P8 RefSeq (mRNA) NM_182972 NM_001077397 NM_001164598 RefSeq (protein) NP_001070865 NP_892017 NP_001158070 Location (UCSC) Chr 1: 234.6 – 234.61 Mb Chr 8: 127.32 – 127.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the ...