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Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). [1] Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. [2]
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene. [5] The IRF family is a group of transcription factors that are involved in signaling for virus responses in mammals along with regulation of certain cellular functions.
54139 Ensembl ENSG00000117595 ENSMUSG00000026638 UniProt O14896 P97431 RefSeq (mRNA) NM_006147 NM_001206696 NM_016851 NM_178083 RefSeq (protein) NP_001193625 NP_006138 NP_058547 Location (UCSC) Chr 1: 209.79 – 209.81 Mb Chr 1: 192.84 – 192.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon regulatory factor 6 also known as IRF6 is a protein that in humans is encoded by ...
Download as PDF; Printable version; In other projects Wikidata item; ... Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, ...
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. [5] [6] [7] IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor (CMP) to differentiate into a ...
Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta, [6] IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes.
IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. [8] [9] In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, lipopolysaccharide (LPS), IL-4, and CD40.
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. [5]