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In immunology, seroconversion is the development of specific antibodies in the blood serum as a result of infection or immunization, ... (HBeAg) is a sign of current ...
HBeAg is a hepatitis B viral protein, produced by the HBcAg reading frame. It is an indicator of active viral replication ; this means the person infected with Hepatitis B can likely transmit the virus on to another person (i.e. the person is infectious).
HBeAg is produced by proteolytic processing of the pre-core protein. In some rare strains of the virus known as hepatitis B virus precore mutants , no HBeAg is present. [ 45 ] The DNA polymerase is encoded by gene P. Gene S is the gene that codes for the surface antigen (HBsAg).
The C gene codes for HBeAg and HBcAg. The C gene has a precore and a core region. If translation is initiated at the precore region, the protein product is HBeAg. If translation begins with the core region, HBcAg is the protein product. HBeAg is a marker of HBV replication and infectivity. The precore region is not necessary for viral replication.
HBcAg is an antigen that can be found on the surface of the nucleocapsid core (the inner most layer of the hepatitis B virus).While both HBcAg and HBeAg are made from the same open reading frame, HBcAg is not secreted as a monomer. [3]
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Patients who developed antibodies against HBsAg (anti-HBsAg seroconversion) are usually considered non-infectious. HBsAg detection by immunoassay is used in blood screening, to establish a diagnosis of hepatitis B infection in the clinical setting (in combination with other disease markers) and to monitor antiviral treatment.
(1) the period that elapses during HBsAg to HBsAb seroconversion, i.e. between the disappearance of surface antigen (HBsAg) from serum and the appearance of HBsAb (anti-HBs), and (2) the period between infection and appearance of HBsAg. During the window of HBsAg to HBsAb seroconversion, IgM anti-core (HBc-IgM) is the only detectable antibody.