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The elimination half-life of levonorgestrel is 24 to 32 hours, although values as short as 8 hours and as great as 45 hours have been reported. [4] [6] About 20 to 67% of a single oral dose of levonorgestrel is eliminated in urine and 21 to 34% in feces. [6]
Whereas the biological half-life of estradiol given by intravenous injection is about 0.5 to 2 hours, the biological half-life of oral estradiol has a range of 13 to 20 hours due to the large and long-lasting pool of estrogen conjugates that is formed during first-pass metabolism and that serves to continuously replenish circulating estradiol ...
The biological activity of norgestrel lies in the levo enantiomer, levonorgestrel, whereas the dextro isomer is inactive. [6] As such, norgestrel is identical in its hormonal activity to levonorgestrel except that it is half as potent by weight. [6]
Norgestimate is a rapidly and completely converted prodrug, mainly of norelgestromin (17β-deacetylnorgestimate or levonorgestrel 3-oxime), but also of levonorgestrel (3-keto-17β-deacetylnorgestimate) to a lesser extent (22 ± 6% of an administered dose or about 40–70 μg) [2] and of levonorgestrel acetate (levonorgestrel 17β-acetate) in ...
Levonorgestrel emergency contraception has an efficiency rate of 89% if it's used correctly within 72 hours after unprotected intercourse. That means 11 out of 100 people who use it after ...
[4] [5] The elimination half-life of etonogestrel is about 25 to 29 hours. [4] [5] Following removal of an etonogestrel-containing implant, levels of the medication were below the limits of assay detection by one week. [4] The major portion of etonogestrel is eliminated in urine and a minor portion is eliminated in feces. [4] [5]
The pharmacokinetics of estradiol, including its bioavailability, metabolism, biological half-life, and other parameters, differ by route of administration. [11] Likewise, the potency of estradiol, and its local effects in certain tissues, most importantly the liver, differ by route of administration as well. [11]
He was, and continues to be, one of the brightest lights in my life. But 10 weeks postpartum, I began to notice I was entirely detached from my body. I did not want others to see me.