Ad
related to: levonorgestrel half life
Search results
Results from the WOW.Com Content Network
The elimination half-life of levonorgestrel is 24 to 32 hours, although values as short as 8 hours and as great as 45 hours have been reported. [4] [6] About 20 to 67% of a single oral dose of levonorgestrel is eliminated in urine and 21 to 34% in feces. [6]
Whereas the biological half-life of estradiol given by intravenous injection is about 0.5 to 2 hours, the biological half-life of oral estradiol has a range of 13 to 20 hours due to the large and long-lasting pool of estrogen conjugates that is formed during first-pass metabolism and that serves to continuously replenish circulating estradiol ...
The unbound ERα has an intracellular half-life of up to 5 days, but this shortens to 3–4 hours once bound to a ligand such as estradiol. [23] [22] Estrogen deprivation can easily increase sensitivity to estrogens like estradiol by 10,000-fold or more, demonstrating a profound capacity of the ERs for upregulation and downregulation. [24]
The biological activity of norgestrel lies in the levo enantiomer, levonorgestrel, whereas the dextro isomer is inactive. [6] As such, norgestrel is identical in its hormonal activity to levonorgestrel except that it is half as potent by weight. [6]
Norgestimate is a rapidly and completely converted prodrug, mainly of norelgestromin (17β-deacetylnorgestimate or levonorgestrel 3-oxime), but also of levonorgestrel (3-keto-17β-deacetylnorgestimate) to a lesser extent (22 ± 6% of an administered dose or about 40–70 μg) [2] and of levonorgestrel acetate (levonorgestrel 17β-acetate) in ...
[4] [5] The elimination half-life of etonogestrel is about 25 to 29 hours. [4] [5] Following removal of an etonogestrel-containing implant, levels of the medication were below the limits of assay detection by one week. [4] The major portion of etonogestrel is eliminated in urine and a minor portion is eliminated in feces. [4] [5]
The pharmacokinetics of estradiol, including its bioavailability, metabolism, biological half-life, and other parameters, differ by route of administration. [11] Likewise, the potency of estradiol, and its local effects in certain tissues, most importantly the liver, differ by route of administration as well. [11]
A review found that the range of the reported elimination half-life of EE in the literature was 13.1 to 27.0 hours. [2] Another review reported an elimination half-life of EE of 10 to 20 hours. [10] However, the elimination half-life of EE has also been reported by other sources to be as short as 7 hours [11] and as long as 36 hours. [9]
Ad
related to: levonorgestrel half life