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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Narcolepsy with cataplexy 347.01 G47.411 Narcolepsy without cataplexy 347.00 G47.419 Narcolepsy due to medical condition 347.10 G47.421 Narcolepsy, unspecified 347.00 G47.43 Recurrent hypersomnia 780.54 G47.13 - Kleine-Levin Syndrome: 327.13 G47.13 - Menstrual-related hypersomnia 327.13 G47.13 Idiopathic hypersomnia with long sleep time 327.11 ...
Autosomal dominant narcolepsy, obesity, and type 2 diabetes 347.00 G47.419 Narcolepsy without cataplexy but with hypocretin deficiency 347.01 G47.411 Narcolepsy with cataplexy but without hypocretin deficiency 347.10 G47.429 Narcolepsy secondary to another medical condition
Cataplexy is the first symptom to appear in about 10% of cases of narcolepsy, [2] caused by an autoimmune destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition between wake and sleep states. [3]
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Generally, diseases outlined within the ICD-10 codes G47 within Chapter VI: Diseases of the nervous system should be included in this category. This category is for articles pertaining to sleep disorders and their treatment.
Pitolisant is indicated in adults for the treatment of narcolepsy. [3] [4] Narcolepsy is a chronic sleep disorder that causes overwhelming daytime drowsiness. [4] Pitolisant is also indicated to improve alertness and reduce excessive daytime sleepiness in adults with obstructive sleep apnea. [5] [12]
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]