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It is effective against fleas, ticks, chewing lice and mosquitoes. [1] The active ingredients are imidacloprid , permethrin , and pyriproxyfen . This product is toxic to cats, [ 2 ] and it is not recommended to use it on dogs which share an environment with cats. [ 1 ]
Imidacloprid has been the most widely used insecticide in the world from 1999 [5] through at least 2018. [6] [7] Because they affect the central nervous system of insects, neonicotinoids kill or deleteriously affect a wide variety of both target and non-target insects. [8]
A fogger or spray insecticide containing an insect growth regulator, such as pyriproxyfen or methoprene can kill eggs and pupae, which are quite resistant to insecticides. A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at doses of ≥0.3 μg. In contrast ...
Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs. Parasitol Res. 2010 Aug;107(3):735-9. doi: 10.1007/s00436-010-1930-y ...
Imidacloprid is more toxic to bees than the organophosphate dimethoate (oral LD 50 152 ng/bee) or the pyrethroid cypermethrin (oral LD 50 160 ng/bee). [34] The toxicity of imidacloprid to bees differs from most insecticides in that it is more toxic orally than by contact. The contact acute LD 50 is 0.024 μg active ingredient per bee. [35]
Of the neonicotinoids tested (imidacloprid, nitenpyram, and dinotefuran), nitenpyram was shown to not have much genotoxic effects or adversely affect the immune system, either through short or chronic exposure in comparison to the other compounds. In a similar study, nitenpyram was shown to have adverse effects on the DNA of Zebrafish. [15]
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