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Fluctuating asymmetry (FA) is often considered to be the product of developmental stress and instability, caused by both genetic and environmental stressors. The notion that FA is a result of genetic and environmental factors is supported by Waddington's notion of canalisation, which implies that FA is a measure of the genome's ability to successfully buffer development to achieve a normal ...
On average, the frontal lobes are asymmetric to the left (the right lobe appears slightly larger than the left), whereas the occipital lobe is asymmetric to the right; the central sulcus and temporal lobe of the right cortical hemisphere are further to the front than those on the left. Overall, these asymmetries are equivalent to a slight ...
Symmetry breaking occurs at several different levels in order to generate the anatomical asymmetry which we observe. These levels include asymmetric gene expression, protein expression, and activity of cells. For example, left–right asymmetry in mammals has been investigated extensively in the embryos of mice. Such studies have led to support ...
RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor. [ 5 ] [ 6 ] [ 7 ] REST is expressly involved in the repression of neural genes in non-neuronal cells.
Asymmetry is the absence of, or a violation of, symmetry (the property of an object being invariant to a transformation, such as reflection). [1] Symmetry is an important property of both physical and abstract systems and it may be displayed in precise terms or in more aesthetic terms. [ 2 ]
Breast cancer is a cancer that develops from breast tissue. [62] Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection , fluid coming from the nipple , a newly inverted nipple, or a red or scaly patch of skin. [ 63 ]
Mammography screening cuts the risk of dying from breast cancer nearly in half. [25] A recent study published in Cancer showed that more than 70 percent of the women who died from breast cancer in their 40s at major Harvard teaching hospitals were among the 20 percent of women who were not being screened.
As knowledge of cancer cell biology develops these classifications are updated. The purpose of classification is to select the best treatment. The effectiveness of a specific treatment is demonstrated for a specific breast cancer (usually by randomized, controlled trials). That treatment may not be effective in a different breast cancer.
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