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Top: An ancestral gene duplicates to produce two paralogs (Genes A and B). A speciation event produces orthologs in the two daughter species. Bottom: in a separate species, an unrelated gene has a similar function (Gene C) but has a separate evolutionary origin and so is an analog.
18626 Ensembl ENSG00000179094 ENSMUSG00000020893 UniProt O15534 O35973 RefSeq (mRNA) NM_002616 NM_001159367 NM_011065 RefSeq (protein) NP_002607 NP_001152839 NP_035195 Location (UCSC) Chr 17: 8.14 – 8.16 Mb Chr 11: 68.99 – 69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene. Function The ...
Human C1orf52 gene neighborhood. B-cell lymphoma 10 (BCL10), B-cell lymphoma antisense 1 (BCL-AS1), dimethylarginine dimethylaminohydrolase 1 (DDAH1), and synapse defective Rho GTPase homolog 2 (SYDE2) genes are located in close proximity to C1orf52 on chromosome 1.
Homology was noticed by Aristotle (c. 350 BC), [1] and was explicitly analysed by Pierre Belon in his 1555 Book of Birds, where he systematically compared the skeletons of birds and humans. The pattern of similarity was interpreted as part of the static great chain of being through the mediaeval and early modern periods: it was not then seen as ...
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]
The paralogs of EVA1C are EVA1A (Eva-1 Homolog A) and EVA1B (Eva-1 Homolog B). [17] [18] The thorny skate (Amblyraja radiata) was found to be the most distant ortholog in EVA1A, EVA1B, and EVA1C. [14] [19] [20] The divergence time of humans and the thorny skate is 464 million years ago. [16]
Chromosome 11 open reading frame 54 (C11orf54) is a protein that in humans is encoded by the C11orf54 gene. [5] The "Homo sapiens" gene, C11orf54 is also known as PTD012 and PTOD12. C11orf54 exhibits hydrolase activity on p-nitrophenyl acetate and acts on ester bonds, though the overall function is still not fully understood by the scientific ...
19361 Ensembl ENSG00000051180 n/a UniProt Q06609 Q08297 RefSeq (mRNA) NM_001164269 NM_001164270 NM_002875 NM_133487 NM_011234 RefSeq (protein) NP_001157741 NP_001157742 NP_002866 NP_597994 NP_035364 Location (UCSC) Chr 15: 40.69 – 40.73 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded ...