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Sometimes the diagnosis must be retrospective, relying on gradual worsening of neurological signs/symptoms, due to the lack of understanding of the pathogenicity driving disease progression. [1] However, the only definite diagnosis of MS is post-mortem autopsy, where lesions typical of MS can be detected through histopathological techniques. [2 ...
The McDonald criteria maintained a scheme for diagnosing MS based solely on clinical grounds but also proposed for the first time that when clinical evidence is lacking, magnetic resonance imaging (MRI) findings can serve as surrogates for dissemination in space (DIS) and/or time (DIT) to diagnose MS. [5] The criteria try to prove the existence ...
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The Poser diagnosis criteria for MS does not allow doctors normally to give an MS diagnosis until a second attack takes place. Therefore, the concept of "clinical MS", for a MS that can be diagnosed is sometimes too strong because until MS diagnosis has been established, nobody can tell whether the disease dealing with is MS. [ citation needed ]
Dr. Cole Harrington, a neurologist at the Ohio State University Wexner Center, agrees that the discoveries could help diagnose MS earlier, and lead to earlier treatment.
Main symptoms of multiple sclerosis. MS lesions can affect any part of the central nervous system so a person with MS can have almost any neurological signs or symptoms. [26] Fatigue is one of the most common symptoms of MS. [27] [28] Roughly 65% of people with MS experience fatigue. Of these, some 15–40% report fatigue as their most ...
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