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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family. [5] [1] [4] [2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado ...
5-Methoxytryptamine (5-MT, 5-MeO-T, or 5-OMe-T), also known as serotonin methyl ether or O-methylserotonin and as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. [3] It has been shown to occur naturally in the body in low levels, especially in the pineal gland.
5-MeO-DMT is a potent and fast-acting psychedelic, which is naturally produced by the Sonoran Desert toad as well as some species of plants. Its short duration –from 20 minutes to one hour– is ...
In addition, 5-MeO-DMT, the O-methylated analogue of bufotenin, which has much greater lipophilicity, is readily able to cross the blood–brain barrier and produce psychedelic effects. [39] Bufotenin prodrug esters , with greater lipophilicity than bufotenin itself, like O -acetylbufotenin and O -pivalylbufotenin , have also shown psychedelic ...
The mechanism that produces the purported hallucinogenic and entheogenic effects of 5-MeO-DiPT is thought to result primarily from 5-HT 2A receptor agonism, although additional mechanisms of action such as monoamine oxidase inhibition (MAOI) may be involved also. [3] The strongest receptor binding affinity for 5-MeO-DiPT is at the 5-HT 1A ...
Beans: 5-MeO-DMT. Up to 12.4% bufotenin. [33] DMT Psychedelic: There have been reports of active use of vilca by Wichi shamans, under the name hatáj. [34] Yopo: Anadenanthera peregrina: Beans: 5-MeO-DMT. Up to 7.4% bufotenin. [33] DMT Psychedelic: Archaeological evidence of insufflation use within the period 500-1000 AD, in northern Chile, has ...
[161] [163] [164] Similarly to DMT, 5-MeO-DMT is a biased agonist of the serotonin 5-HT 2A receptor, with minimal β-arrestin2 recruitment, and likewise has been associated with little tolerance to its hallucinogenic effects. [165] [140] As DMT has been shown to have slightly better efficacy (EC 50) at human serotonin 2C receptor than at the 2A ...
Individual sensitivity to 5-MeO-DMT varies. It has been documented that the threshold dose in some individuals is as much as 10 mg insufflated [25] requiring over 24 grams of beans for an effective dose of 5-MeO-DMT. At up to 0.16% (1.6 mg per gram) DMT, an effective 40 mg dose of insufflated DMT would require 25 grams or more.