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The Canadian formulation of Preparation H includes a yeast extract called Biodyne which was removed in 1995 from the formulation sold in the United States. This yeast extract was the primary ingredient of the original formulation by inventor George Sperti , [ 5 ] [ 6 ] and Pfizer believes that it removes wrinkles from skin and heals dry ...
George Speri Sperti (January 17, 1900, Covington, Kentucky – April 29, 1991, Cincinnati, Ohio) was an Italian-American who invented Preparation H hemorrhoid medication. He also invented the Sperti Ultraviolet Lamp, Aspercreme for pain relief, and KVa Power Meter. [1] [2] Sperti graduated from the University of Cincinnati in 1923. Shortly ...
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One customer review praised the fast relief: "Within 20 minutes, I forgot the pain was there in the first place." Another customer was pleased with the size for the price: "A little goes a long way.
The texture of topical gels is less greasy as it contains a higher proportion of water compared with cream and ointment. [ 3 ] [ 1 ] [ 2 ] [ 8 ] These gels have an excellent spreading property and cooling effect due to solvent evaporation, and also has a higher retention time on the skin.
The skin membrane is the area (A) for the topical drug molecules to travel across. The skin membrane thickness is known as (h) in the expression, and it determines the diffusion path length. [4] The (C) is the concentration of the diffusing substance across the skin layers and the (D) is the diffusion coefficient.
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