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Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6]
Common side effects when used as a cream are limited to the skin and include skin redness, peeling, and sun sensitivity. [10] When taken by mouth, side effects include hypertriglyceridemia, hypercholesterolemia, shortness of breath, headache, numbness, depression, skin dryness, itchiness, hair loss, vomiting, muscle pains, and vision changes. [8]
Differin gel is an NBC Select staff favorite and Wellness Award winner for best acne treatment — it contains 0.1% adapalene, which is an over-the-counter retinoid often used to treat acne ...
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
Topical steroids are the topical forms of corticosteroids.Topical steroids are the most commonly prescribed topical medications for the treatment of rash and eczema.Topical steroids have anti-inflammatory properties and are classified based on their skin vasoconstrictive abilities. [1]
Amcinonide exhibits side effects common among other corticosteroids. While these reactions are uncommon for most delivery vehicles, the use of occlusive dressings increases the likelihood of such effects. [5] These include burning, itching, skin dryness and irritation, acne/ pimples, skin atrophy, blistering, and/ or skin discoloration.
Serious side effects may include allergic reactions (anaphylaxis), increased risk of osteoporosis, glaucoma and cataracts, thrush in the mouth or throat, growth retardation in children, bronchospasms, adrenal insufficiency and weakened immune system which causes increased susceptibility to infections. The topical (skin cream) version may cause:
Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia. [8] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome. [8] Use in pregnancy and breastfeeding is of unclear safety. [12] Clobetasol is believed to work by activating steroid receptors. [8]