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Monoclonal B-cell lymphocytosis; Other names: monoclonal lymphocytosis of undetermined significance: Specialty: Hematology, oncology: Symptoms: None: Complications: May progress to chronic lymphocytic leukemia or certain lymphoma types; increased risk of developing non-hematologic cancers, serious infections, and kidney disease
Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow.
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma ...
Recently, however, monoclonal B-cells with some key characteristics of the malignant B-cells in FL or MCL have been found to accumulate in one or more lymphoid tissues. These accumulations are localized, non-destructive (i.e. not effacing a tissue's normal architecture), premalignant, and therefore now regarded as in situ disorders similar to ...
[19] [20] CLL/SLL MBL consist of two groups: low-count CLL/SLL MBL has monoclonal B-cell blood counts of <0.5x10 9 cells/liter (i.e. 0.5x10 9 /L) while high-count CLL/SLL MBL has blood monoclonal B-cell counts ≥0.5x10 9 /L but <5x10 9 /L. [21] Individuals with blood counts of these monoclonal B-cells >5x10 9 /L are diagnosed as having CLL ...
In immunology, immunoproliferative disorders are disorders of the immune system that are characterized by the abnormal proliferation of the primary cells of the immune system, which includes B cells, T cells and natural killer (NK) cells, or by the excessive production of immunoglobulins (also known as antibodies). [citation needed]
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Monoclonal B-cell lymphocytosis has a low risk of ... Treatment is generally considered necessary when the person shows signs and symptoms such as low blood cell ...