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Chloroquine is also a lysosomotropic agent, meaning it accumulates preferentially in the lysosomes of cells in the body. [citation needed] The pK a for the quinoline nitrogen of chloroquine is 8.5, meaning it is about 10% deprotonated at physiological pH (per the Henderson-Hasselbalch equation).
One such cocktail – hydroxychloroquine combined with a high dose of zinc (as a sulfate, 220 mg (50 mg elemental Zn) per day for five days, a zinc dose ~4 times higher than the reference daily intake level) [63] and an approved antibiotic, either azithromycin or doxycycline – began in May as a Phase IV trial in New York State. [65]
Chloroquine and hydroxychloroquine are anti-malarial medications also used against some auto-immune diseases. [51] Chloroquine, along with hydroxychloroquine, was an early experimental treatment for COVID-19. [52] Neither drug has been useful to prevent or treat SARS-CoV-2 infection.
Limiting your alcohol consumption, ideally to less than 2 drinks per day for men or 1 drink per day or less for women. Including more stress-relieving activities in your daily routine.
General guidance from the U.S. Centers for Disease Control and Prevention (CDC) states that limiting alcohol (no more than two drinks per day for men and one for women) is essential for our health.
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It has a weak blood schizonticidal activity and is not recommended for therapy of acute infection. However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine resistance). 3 mg/kg is the advised dosage per day, (hence approximate adult dosage is 200 mg). [13]
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