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A non-genetic form of haemophilia is caused by autoantibodies against factor VIII and so is known as acquired haemophilia A. [15] It is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors. [43]
Haemophilia A (or hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally and externally.
Contaminated hemophilia blood products were a serious public health problem in the late 1970s up to 1985. Hemophilia A causes a deficiency in Factor VIII , a protein required for blood clotting. Factor VIII injections are a common treatment to prevent or stop bleeding in people with hemophilia A. [ 1 ]
Acquired haemophilia A (AHA) is a rare but potentially life-threatening bleeding disorder characterized by autoantibodies directed against coagulation factor VIII.These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous bleeding in patients with no previous history of a bleeding disorder.
Haemophilia B, also spelled hemophilia B, is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (haemophilia A). [3]
"Hemophilia: The Royal Disease" Yelena Aronova-Tiuntseva and Clyde Freeman Herreid; Family tree of Queen Victoria and her descendants; Haemophilia in Queen Victoria's Descendants. Archived 2006-11-18 at the Wayback Machine; Victor A. McKusick (August 1965). "The Royal Hemophilia". Scientific American. pp. 88– 95
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