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Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.
The structure of apixaban, before adjusting the moiety's for maximum potency. Apixaban. The 13F moiety intermediate before apixaban was fully developed. During the SAR development of apixaban there were three groups that needed to be tested to attain maximum potency and bioavailability.
The dose is based on recommendations for treatment rather than prevention, except if prevention is the main indication. Generally there is only one DDD for all formulations of a drug, however exceptions are made if some formulations are typically used in significantly different strengths (e.g., antibiotic injection in a hospital vs tablets in ...
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Braden Huff scored 25 points on 11-of-12 shooting to help No. 13 Gonzaga cruise to a 102-72 victory over Nicholls on Wednesday night at Spokane, Wash. Graham Ike added 20 points and Ryan Nembhard ...
[5] [19] The Essential Medicines List (EML) was updated in July 2023 to its 23rd edition. This list contains 1200 recommendations for 591 drugs and 103 therapeutic equivalents. [20] A separate list for children up to 12 years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007 and is in its 9th ...
Every year, celebrities try to capitalize on the holiday season by releasing festive music. Singers like Mariah Carey, Ariana Grande, and Michael Bublé managed to perfect the cheesy art form.
Once or twice daily subcutaneous injection for treatment of venous thromboembolism and in unstable angina instead of intravenous infusion of high-dose heparin. There is no need to monitor the APTT coagulation parameter as required for high-dose heparin. [26] Possibly a smaller risk of bleeding. Smaller risk of osteoporosis in long-term use.