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2. CD4+/CD8+ ratio - Wikipedia

   en.wikipedia.org/wiki/CD4+/CD8+_ratio

   In COVID-19 B cell, natural killer cell, and total lymphocyte counts decline, but both CD4 + and CD8 + cells decline to a far greater extent. [12] Low CD4 + predicted greater likelihood of intensive care unit admission, and CD4 + cell count was the only parameter that predicted length of time for viral RNA clearance.

3. ZAP70 - Wikipedia

   en.wikipedia.org/wiki/ZAP70

   Due to its role in lymphocyte signaling, ZAP-70 has been associated with several diseases affecting lymphocytes. ZAP-70 expression is a significant indicator of the survival of lymphocytes and has been notably associated with chronic lymphocytic leukemia (CLL). [11] CLL is a cancer that develops from overproduction of B cells in the bone marrow.

4. Helper/suppressor ratio - Wikipedia

   en.wikipedia.org/wiki/Helper/suppressor_ratio

   Normal values (95% confidence intervals) are approximately 30-60% CD4 and 10-30% CD8 depending on age (ratio 0.9 to 3.7 in adults). [1] One reason for abnormal results is the loss of CD4-positive cells to the human immunodeficiency virus (HIV) infection. The loss of CD4-positive cells to HIV infection can result in various distortions in the ...

5. T helper 3 cell - Wikipedia

   en.wikipedia.org/wiki/T_helper_3_cell

   The presence of CD69 is not specific for T h 3 cells, since it is expressed on other lymphocytes, mainly subsets that are tissue resident. [8] The latency-associated peptide (LAP) noncovalently bounds TGF-β and can be expressed by many cells of the immune system. [9] In tumors T h 3 cells can express lymphocyte activation gene-3 (LAG3).

6. Flow cytometry bioinformatics - Wikipedia

   en.wikipedia.org/wiki/Flow_cytometry_bioinformatics

   Over the years, updates were incorporated to adapt to technological advancements in both flow cytometry and computing technologies with FCS 2.0 introduced in 1990, [61] FCS 3.0 in 1997, [62] and the most current specification FCS 3.1 in 2010. [63] FCS used to be the only widely adopted file format in flow cytometry.

7. CD3 (immunology) - Wikipedia

   en.wikipedia.org/wiki/CD3_(immunology)

   CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

8. Cluster of differentiation - Wikipedia

   en.wikipedia.org/wiki/Cluster_of_differentiation

   The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).

9. Monoclonal B-cell lymphocytosis - Wikipedia

   en.wikipedia.org/wiki/Monoclonal_B-cell_lymphocy...

   This increase must persist for at least 3 months. [1] The lymphocyte subtypes are B-cells that share certain features with the abnormal clones of lymphocytes that circulate in chronic lymphocytic leukemia/small lymphocyte lymphoma (CLL/SLL) or, less frequently, other types of B-cell malignancies. Some individuals with these circulating B-cells ...