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Hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), is for women with menopausal symptoms. It is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesterone hormones, or in the case of the surgically or prematurely menopausal, that it may prolong life and may reduce incidence of dementia. [1]
Vaginal weight had a 1.46x increase after a two-week treatment of 10 mg/kg/day of ospemifene. [10] The number of progesterone receptors was increased in the vaginal stroma and epithelium, which indicates that ospemifene has "estrogenic activity." [10] Two 12-week phase 3 clinical trials were performed for ospemifene. [14]
While a 2018 review found that taking progesterone and estrogen together can decrease this risk, [53] other reviews reported an increased risk of blood clots and pulmonary embolism when estrogen and progestogen were combined, particularly when treatment was started 10 years or more after menopause and when the women were older than 60 years.
When preliminary results of the Women's Health Initiative clinical trial were published in 2003, they upended menopause care in the U.S. The study linked hormone therapy — a form of treatment ...
Hormone replacement therapy (HRT) should be offered as the first treatment to ease menopause symptoms such as hot flushes and night sweats, according to the latest advice from health watchdog NICE.
Nice stressed that the symptoms women experience are real and treatments are available. Women with menopause symptoms ‘should be offered HRT as first-line treatment’ Skip to main content
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