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Researchers found that removing the IL-11 gene or using an anti-IL-11 antibody dramatically increased the lifespan and health of aging mice. ... or extend life without improving health, IL-11 does ...
The results were significant: Researchers found that mice treated with the anti-IL-11 drug showed a median lifespan extension of 22.5% in males and 25% in females, living an average of 155 weeks ...
[8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.
They also showed a normal life span. In a study in which a single 50 μg/kg subcutaneous dose was administered to eighteen healthy men, the peak serum concentration (C max) of 17.4 ± 5.4 ng/mL was reached at 3.2 ± 2.4 h (T max) following dosing. The terminal half-life was 6.9 ± 1.7 hours.
"The first 1000-year-old is probably only ~10 years younger than the first 150-year-old."–Aubrey de Grey, 2005 [1]. In the life extension movement, longevity escape velocity (LEV), actuarial escape velocity [2] or biological escape velocity [3] is a hypothetical situation in which one's remaining life expectancy (not life expectancy at birth) is extended longer than the time that is passing.
By the way, if you want to add up to 11 years to your life, you don't have to walk your daily 111 minutes all at once: That amount can be broken up throughout the day. Check out Women's Health 's ...
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
Though the concept per se has been present in the life extension community since at least the 1970s (for example, Robert Wilson, essay Next Stop, Immortality, 1978 [67]). 2004 As a result of the use of anti-aging therapy, a team of scientists led by Stephen Spindler managed to extend the life of a group of already adult mice to an average of 3. ...