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The number of pseudogenes in the human genome is on the order of 13,000, [27] and in some chromosomes is nearly the same as the number of functional protein-coding genes. Gene duplication is a major mechanism through which new genetic material is generated during molecular evolution .
•List of human protein-coding genes page 2 covers genes EPHA1–MTMR3 •List of human protein-coding genes page 3 covers genes MTMR4–SLC17A7 •List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol.
Estimates of the number of coding genes in the human genome reached upwards of 100,000 prior to the human genome project, [18] but since have dwindled to as low as 19,000 following completion of that massive sequencing effort and subsequent refinements. [1]
Along with identifying all of the approximately 20,000–25,000 genes in the human genome (estimated at between 80,000 and 140,000 at the start of the project), the Human Genome Project also sought to address the ethical, legal, and social issues that were created by the onset of the project. [85]
The total number of protein-coding genes (the Earth's proteome) is estimated to be 5 million sequences. [121] Although the number of base-pairs of DNA in the human genome has been known since the 1950s, the estimated number of genes has changed over time as definitions of genes, and methods of detecting them have been refined.
The total number of noncoding genes in the human genome is controversial. Some scientists think that there are only about 5,000 noncoding genes while others believe that there may be more than 100,000 (see the article on Non-coding RNA). The difference is largely due to debate over the number of lncRNA genes. [18]
In genetics, the gene density of an organism's genome is the ratio of the number of genes per number of base pairs, usually written in terms of a million base pairs, or megabase (Mb). The human genome has a gene density of 11-15 genes/Mb, while the genome of the C. elegans roundworm is estimated to have 200.
Genome size Number of chromosomes Number of genes predicted Organization Year of completion Arabidopsis thaliana Ecotype:Columbia: Wild mustard Thale Cress Model plant 135 Mb [10] 5 25,498, [11] 27,400, [12] 31,670 (UniProt) Arabidopsis Genome Initiative [13] 2000 [11] Cyanidioschyzon merolae Strain:10D: Red algae: Simple eukaryote: 16.5 Mb 20 ...