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  2. Progesterone receptor - Wikipedia

    en.wikipedia.org/wiki/Progesterone_receptor

    The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, [5] [6] [7] it has two isoforms, PR-A and PR-B, that differ in their molecular ...

  3. Selective progesterone receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_progesterone...

    A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone.A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some ...

  4. Pharmacodynamics of progesterone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    Progesterone is a progestogen, or an agonist of the nuclear progesterone receptors (PRs), the PR-A, PR-B, and PR-C. [1] In one study, progesterone showed EC 50 Tooltip half-maximal effective concentration values of 7.7 nM for the human PR-A and 8.0 nM for the human PR-B. [5] In addition to the PRs, progesterone is an agonist of the membrane progesterone receptors (mPRs), including the mPRα ...

  5. Ulipristal acetate - Wikipedia

    en.wikipedia.org/wiki/Ulipristal_acetate

    Two intermittent 3-months treatment courses of ulipristal acetate 10 mg resulted in amenorrhea at the end of the first treatment course in 79.5%, at the end of the second course in 88.5% of subjects. Mean myoma volume reduction observed during the first treatment course (−41.9%) was maintained during the second one (−43.7%). [ 22 ]

  6. Progestogen (medication) - Wikipedia

    en.wikipedia.org/wiki/Progestogen_(medication)

    Progesterone interacts with membrane progesterone receptors, but interaction of progestins with these receptors is less clear. [ 165 ] [ 166 ] In addition to their progestogenic activity, many progestogens have off-target activities such as androgenic , antiandrogenic , estrogenic , glucocorticoid , and antimineralocorticoid activity.

  7. High-dose estrogen therapy - Wikipedia

    en.wikipedia.org/wiki/High-dose_estrogen_therapy

    Estrogen receptor-positive breast cancer in women [1] As a means of androgen deprivation therapy for prostate cancer and benign prostatic hyperplasia in men [7] [8] [10] In combination with progestins for endometriosis in women. Although initially used alone, progestins were added in the 1960s and 1970s. [11]

  8. Progesterone (medication) - Wikipedia

    en.wikipedia.org/wiki/Progesterone_(medication)

    Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.

  9. Medrogestone - Wikipedia

    en.wikipedia.org/wiki/Medrogestone

    Medrogestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. [2] It has weak antiandrogenic , glucocorticoid , and antimineralocorticoid activity and no other important hormonal activity.