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The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and was made available in 1960 by Hoffmann–La Roche, which followed with the development of diazepam (Valium) three years later, in 1963. [1]
Chlordiazepoxide (initially called methaminodiazepoxide) was the first benzodiazepine to be synthesized in the mid-1950s. The synthesis was derived from work on a class of dyes, quinazoline-3-oxides. [33] It was discovered by accident when in 1957 tests revealed that the compound had hypnotic, anxiolytic, and muscle relaxant effects.
Librium, based on the R0 6-690 compound discovered by Sternbach in 1956, was approved for use in 1960. In 1963, its improved version, Valium, was released and became astonishingly popular: between 1969 and 1982, it was the most prescribed drug in America, with over 2.3 billion doses sold in its peak year of 1978.
Benzodiazepines. Beta-blockers. Other medications, like buspirone. As a whole, ... (MAOIs) are older antidepressants that were first discovered in the 1950s by clinical researchers. While they don ...
The first tricyclic antidepressant (TCA), imipramine was discovered. 1958. Aaron B. Lerner et al. of Yale University isolated the hormone melatonin, which was found to regulate the circadian rhythm. 1960s. Aaron T. Beck developed cognitive therapy. 1960. The first benzodiazepine, chlordiazepoxide, under the trade name Librium was introduced. 1961
In 1958, Leo Sternbach discovered the first benzodiazepine, chlordiazepoxide (Librium). Dozens of other benzodiazepines have been developed and are in use, some of the more popular drugs being diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), and lorazepam (Ativan). Due to their far superior safety and therapeutic properties ...
Amairani Salinas was 32 weeks pregnant with her fourth child in 2023 when doctors at a Texas hospital discovered that her baby no longer had a heartbeat. ... a benzodiazepine commonly prescribed ...
Finally, note that the benzodiazepine core is a privileged scaffold, which has been used to derive drugs with diverse activity that is not limited to the GABA A modulatory action of the classical benzodiazepines, [60] such as devazepide and tifluadom, however these have not been included in the list below. 2,3-benzodiazepines such as tofisopam ...