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Organophosphate poisoning is poisoning due to organophosphates (OPs). [4] Organophosphates are used as insecticides , medications, and nerve agents . [ 4 ] Symptoms include increased saliva and tear production, diarrhea , vomiting, small pupils , sweating, muscle tremors, and confusion. [ 2 ]
In the treatment of organophosphate toxicity, cholinesterase reactivators such as Pralidoxime reactivate inhibited AChE at peripheral nicotinic receptors.Since AChE mediates effects on both nicotinic and muscarinic receptors, cholinesterase reactivators are co-administered with muscarinic antagonists, primarily atropine.
Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase. [1] It is used to treat organophosphate poisoning [2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.
Pralidoxime, another antidote, can be considered to reactivate inhibited acetylcholinesterase enzymes, although this is often less important for carbamate poisoning than it is for organophosphate poisoning. [1] The most common cause of death following carbamate poisoning is respiratory failure. [3]
After some hours diarrhea and vomiting may occur. People who inhaled sulfotep are often disorientated and have difficulties to breath. A poisonous dose may lead to a coma or death after 24 hours. The point at 24 hours after the poisoning is very important. If the dose is not lethal, the symptoms will slowly disappear after the point of 24 hours.
In the US, it is the most commonly used organophosphate insecticide. [6] A malathion mixture with corn syrup was used in the 1980s in Australia and California to combat the Mediterranean fruit fly. [7] In Canada and the US starting in the early 2000s, malathion was sprayed in many cities to combat west Nile virus. [8]
After arriving back home, the couple sought medical attention and were diagnosed with "likely organophosphate poisoning." Organophosphates are a type of human-made chemicals that are widely used ...
An ATNAA (Antidote Treatment Nerve Agent Autoinjector) is any of a variety of autoinjectors in use with the US Armed Forces. An autoinjector is a medical device designed to deliver a single dose of a particular (typically life-saving) drug. Most autoinjectors are spring-loaded syringes. By design, autoinjectors are easy to use and are intended ...