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Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells (red blood cells, white blood cells, platelets, monocytes, lymphocytes, etc.). If only two parameters from the complete blood count are low, the term bicytopenia can be used. The diagnostic approach is the same as for pancytopenia.
Once pancytopenia develops, the prognosis is poor. Studies have shown 30% of CAMT patients die from bleeding complications, and another 20% die from complications related to hematopoietic stem cell transplantation. [3]
Symptoms may begin early in life or in adulthood and mainly affect the liver, spleen, and bone. Enlarged liver and grossly enlarged spleen (together hepatosplenomegaly) are common; [3] the spleen can rupture and cause additional complications.
Laboratory findings include pancytopenia, marrow aplasia, abnormal liver enzymes, and electrolyte imbalance (when diarrhea is present). [citation needed] TA-GvHD can be suspected from a biopsy of the affected skin or liver, [4] and established by HLA analysis of the circulating lymphocytes. This testing can identify circulating lymphocytes with ...
If pancytopenia is present, bone marrow failure [4] must be considered and evaluation for bone marrow failure syndromes or aplastic anemia must be pursued. Treatment is dependent on the etiology and may include replacement of blood products as patients can develop severe anemia.
Symptoms. Atherosclerosis is often referred to as a silent killer, since symptoms often don’t appear or are minimal until it causes severe cardiovascular disease or other complications.
In the less common instance that white blood cells are attacked, symptoms may include increased proneness to infection, fevers, and/or mouth sores. [ 6 ] [ 7 ] It has been variously reported that between 7.8% [ 4 ] and 23% [ 8 ] of patients who have autoimmune hemolytic anemia , will also have thrombocytopenia and thus Evans syndrome.
Macrophage activation syndrome is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA).
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