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A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. [1] If the cell grows uncontrollably, it will result in cancer . When a tumor suppressor gene is mutated, it results in a loss or reduction in its function.
13176 Ensembl ENSG00000187323 ENSMUSG00000060534 UniProt P43146 P70211 RefSeq (mRNA) NM_005215 NM_007831 RefSeq (protein) NP_005206 NP_031857 Location (UCSC) Chr 18: 52.34 – 53.54 Mb Chr 18: 71.39 – 72.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Netrin receptor DCC, also known as DCC, or colorectal cancer suppressor is a protein which in humans is encoded by the DCC gene ...
SDPR functions as a metastasis suppressor in breast cancer, potentially by priming cells to apoptosis. [8] Cancer cells suppress the gene via promoter DNA methylation hence exemplifies the significance of epigenetic changes in cancer progression. [9] [10] KISS1 is found in melanoma and breast cancers. It acts by synthesizing a protein receptor.
To tightly control cell division, cells have processes within them that prevent cell growth and division. These processes are orchestrated by proteins encoded by tumor suppressor genes. These genes take information from the cell to ensure that it is ready to divide, and will halt division if not (when the DNA is damaged, for example). In cancer ...
The p53 p63 p73 family is a family of tumor suppressor genes. [1] [2] This gene family codes the proteins: p53; TP73L (also known as "p63") p73; They are sometimes considered part of a "p53 family." When overexpressed, these proteins are known to be involved in tumor pathogenesis. [3]
11334 80385 Ensembl ENSG00000114383 ENSMUSG00000010054 UniProt O75896 Q9WVF8 RefSeq (mRNA) NM_007275 NM_019742 RefSeq (protein) NP_009206 NP_062716 Location (UCSC) Chr 3: 50.32 – 50.33 Mb Chr 9: 107.44 – 107.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene. This gene is a highly conserved lung ...
Research shows gene defect's role in autism-like behavior; Dance Your PhD 2017 : A Story of Tumor Suppression Deepti Mathur. PTEN and cancer explained in dance. A metabolic pathway uses glutamine to create a component of DNA. This pathway is regulated in part by PTEN. Loss of PTEN allows the pathway to go into overdrive, leading to cancer.
Under this model, cancer arises as the result of a single, isolated event, rather than the slow accumulation of multiple mutations. [4] The exact function of some tumor suppressor genes is not currently known (e.g. MEN1, WT1), [5] but based on these genes following the Knudson "two-hit" hypothesis, they are strongly presumed to be suppressor genes.