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The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components.
At present, guided bone regeneration is predominantly applied in the oral cavity to support new hard tissue growth on an alveolar ridge to allow stable placement of dental implants. When bone grafting is used in conjunction with sound surgical technique, guided bone regeneration is a reliable and validated procedure.
The type of growth maintained by chondroblasts is called appositional bone growth and increases the birth of the affected tissue. Perichondrium, and thus chondroblasts, are not found on the articular cartilage surfaces of joints. [citation needed] [original research?]
The first step in the process is the formation of bone spicules which eventually fuse with each other and become trabeculae. The periosteum is formed and bone growth continues at the surface of trabeculae. Much like spicules, the increasing growth of trabeculae result in interconnection and this network is called woven bone.
Bone tissue is a dynamic system with active metabolism. [24] Bone tissue remodelling or bone remodeling is a successive chain of old bone matrix removal and its replacement with a new one. [25] These processes make a child’s skeleton grow and extend, while childhood is characterized by bone tissue growth rather than its resorption.
Osseointegration is also defined as: "the formation of a direct interface between an implant and bone, without intervening soft tissue". [1]An osseointegrated implant is a type of implant defined as "an endosteal implant containing pores into which osteoblasts and supporting connective tissue can migrate". [2]
Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter.
Bone cancer: bone metastases located in the spine, pelvis and long bones can be treated with image-guided ablative techniques (RFA, MWA, cryoablation, electrocorporation) with or without injection of cement (cementoplasty) to stabilize the bone. These treatments may be palliatively for bone metastases pain, or for some cases such as osteoid ...
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