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  2. Astressin-B - Wikipedia

    en.wikipedia.org/wiki/Astressin-B

    Astressin-B is a nonselective corticotropin releasing hormone antagonist that reduces the synthesis of adrenocorticotropic hormone and cortisol. [1] It reduces the synthesis of adrenocorticotropic hormone and improves the sexual drive of rats under stressing conditions. [2] Astressin-B is able to delay the emptying of solid food in mice. [3]

  3. Corticotropin-releasing hormone antagonist - Wikipedia

    en.wikipedia.org/wiki/Corticotropin-releasing...

    Antagonists acting at CRF-2 have also been developed, such as the peptide Astressin-B, [8] but so far no highly selective agents for CRF-2 subtypes are available. There is an increased interest in research on the combinational treatment of CRF-1 and CRF-2 antagonists, along with concurrent SSRI treatment, [5] for the treatment of anxiety disorders.

  4. U.S. FDA places clinical hold on Biomea's diabetes trials

    www.aol.com/news/u-fda-places-hold-biomeas...

    The drug, BMF-219, was being tested in an early-to-mid stage study for type 2 diabetes and a mid-stage study in type 1 diabetes. The drug developer said the FDA cited deficiencies based on the ...

  5. Pacific Northwest Diabetes Research Institute - Wikipedia

    en.wikipedia.org/wiki/Pacific_Northwest_Diabetes...

    The first such institute in the Pacific Northwest, it was created in 1956 by William B. Hutchinson as the Pacific Northwest Research Foundation (PNRF). A second-generation physician, founder Hutchinson (1909–1997) was a surgeon and an older brother of Major League Baseball pitcher and manager Fred Hutchinson, who died of lung cancer at age 45 in 1964.

  6. Semaglutide - Wikipedia

    en.wikipedia.org/wiki/Semaglutide

    In June 2008, a phase II clinical trial began studying semaglutide, a once-weekly diabetes therapy as a longer-acting alternative to liraglutide. [49] [50] It was given the brand name Ozempic. Clinical trials started in January 2016 and ended in May 2017. [23] [51]

  7. Investigator's brochure - Wikipedia

    en.wikipedia.org/wiki/Investigator's_brochure

    An IB is intended to provide the investigator with insights necessary for management of study conduct and study subjects throughout a clinical trial. An IB may introduce key aspects and safety measures of a clinical trial protocol, such as: Dose (of the study drug) Frequency of dosing interval; Methods of administration; Safety monitoring ...

  8. How to Stop a Large Dog From Breaking Into Sprints on Walks - AOL

    www.aol.com/stop-large-dog-breaking-sprints...

    Shock Absorbers. There are several types of shock absorbers specifically designed for leashes. A bungee leash extender can, to some degree, help diffuse force and absorb shock when your dog darts ...

  9. Why “Walk the Line” director James Mangold circled back to ...

    www.aol.com/why-walk-line-director-james...

    Still, Holbrook was initially apprehensive about playing such an iconic musician. "I was shocked and a little daunted," he recalls of his response to Mangold's offer for the role.

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