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In a typical set of rules, a platelet donor must weigh at least 50 kg (110 lb) and have a platelet count of at least 150 x 10 9 /L (150,000 platelets per mm³). [2] One unit has greater than 3×10 11 platelets. Therefore, it takes 2 liters of blood having a platelet count of 150,000/mm³ to produce one unit of platelets.
Whole blood (WB) is human blood from a standard blood donation. [1] It is used in the treatment of massive bleeding, in exchange transfusion, and when people donate blood to themselves. [1] [2] One unit of whole blood (approximately 450 mL) brings up hemoglobin levels by about 10 g/L. [3] [4] Cross matching is typically done before the blood is ...
The yield is normally the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets from apheresis be equal to or greater than 3.0 × 10 11 in number and have a pH of equal to or greater than 6.2 in 90% of the products tested and must be used within five days. Leukapheresis – leukocytes (white blood ...
During a platelet donation, the blood is drawn from the patient and the platelets are separated from the other blood components. The remainder of the blood, red blood cells, plasma, and white blood cells are returned to the patient. This process is completed several times for a period of up to two hours to collect a single donation. [78]
Post-transfusion purpura (PTP) is a delayed adverse reaction to a blood transfusion or platelet transfusion that occurs when the body has produced alloantibodies to the allogeneic transfused platelets' antigens. These alloantibodies destroy the patient's platelets leading to thrombocytopenia, a rapid decline in platelet count. [1]
An alternative donor is a mother who is, of course, negative for the culprit antigen. However, she must meet general criteria for donation and platelets received from the mother must be washed to remove the offending alloantibody and irradiated to reduce the risk of graft-versus-host disease. If platelet transfusions are needed urgently ...
Platelets are either isolated from collected units of whole blood and pooled to make a therapeutic dose, or collected by platelet apheresis: blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor in a closed loop. The industry standard is for platelets to be tested for ...
On 21 March 2017, the PyPy project released version 5.7 of both PyPy and PyPy3, with the latter introducing beta-quality support for Python 3.5. [24] On 26 April 2018, version 6.0 was released, with support for Python 2.7 and 3.5 (still beta-quality on Windows). [25] On 11 February 2019, version 7.0 was released, with support for Python 2.7 and ...