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AC almost always affects the lower lip and only rarely the upper lip, probably because the lower lip is more exposed to the sun. [7] In the unusual cases reported where it affects the upper lip, this may be due to upper lip prominence. [7] The commissures (corners of the mouth) are not usually involved. [2] [6]
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
For basal cell carcinoma excisions on the lower lip the wound can be covered with a keystone flap. A keystone flap is achieved by creating a flap below the defect and pulling it superiorly to cover the wound. This can be performed if there is enough skin laxity to cover the defect and adequate blood supply to the flap. [45]
The skin of the face is thicker than the skin overlying the lips where blood vessels are closer to the surface. As a consequence, the margin of the lips shows a transition between the thicker and thinner skin, represented by the vermilion border. It therefore has the appearance of a sharp line between the coloured edge of the lip and adjoining ...
"I apply first thing in the morning, after any snack or meal, before and after workouts in the evening, after brushing my teeth, after showering," one lip balm fan says.
Some drugs are inactive in the digestive tract, but this can be avoided if held between the upper lip and gum. This prevents the substances from getting swallowed with salivation , as would normally occur between the lower lip and gum, permitting slow release of the drug to prolong the duration of action.
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F – fluorouracil (5-FU), a pyrimidine analog and antimetabolite which incorporates into the DNA molecule and stops DNA synthesis; OX – oxaliplatin (Eloxatin), a platinum-based antineoplastic agent, which inhibits DNA repair and/or DNA synthesis;