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The predominant cause of nutritional optic neuropathy is thought to be deficiency of B-complex vitamins, particularly thiamine [2] (vitamin B 1), cyanocobalamin (vitamin B 12) and recently copper. [3] Deficiency of pyridoxine (vitamin B 6), niacin (vitamin B 3), riboflavin (vitamin B 2), and/or folic acid also seems to play a role. Those ...
The optic nerve can be damaged when exposed to direct or indirect injury. Direct optic nerve injuries are caused by trauma to the head or orbit that crosses normal tissue planes and disrupts the anatomy and function of the optic nerve; e.g., a bullet or forceps that physically injures the optic nerve.
Patients typically present with pain associated with visual loss. [1] CRION is a clinical diagnosis of exclusion , and other demyelinating, autoimmune, and systemic causes should be ruled out. [ 3 ] An accurate antibody test which became available commercially in 2017 has allowed most patients previously diagnosed with CRION to be re-identified ...
Existing treatments aim to suppress the immune system to prevent further damage to nerve cells. A new study has developed a treatment that can help regenerate myelin with the potential to stop and ...
Toxic optic neuropathy refers to the ingestion of a toxin or an adverse drug reaction that results in vision loss from optic nerve damage. Patients may report either a sudden loss of vision in both eyes, in the setting of an acute intoxication, or an insidious asymmetric loss of vision from an adverse drug reaction.
The optic nerve is the bundle of axons that carry the visual signals from the eye to the brain. This optic nerve must penetrate through the wall of the eye, and the hole to accommodate this is usually 20-30% larger than the nerve diameter. In some patients the optic nerve is nearly as large as the opening in the back of the eye, and the optic ...
The exact mechanism of optic nerve ischemia in these cases remains unclear, but contributing factors may include hypotension, anemia, hypoxia, and changes in the autoregulation of optic nerve arterial blood flow. The incidence of ischemic optic neuropathy leading to vision loss following general surgeries ranges between 0.1% and 0.002%.
It presents with visual loss and signs of optic nerve dysfunction, such as loss of color vision, afferent pupil defect, and sometimes abnormalities of the optic disc. The clinical features of AON can be variable and present in several unilateral or bilateral forms: Acute anterior or retrobulbar optic neuritis sometimes associated with pain ...
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