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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Melatonin supplements for sleep come with side effects and their use may raise safety concerns, experts say. There's little evidence they help with insomnia.
Melatonin supplements can lull you to sleep on restless nights, but too much may lead to more rest disruption; here's what sleep experts say about proper dosage for adults and children.
Overall, side effects occurred in 6% with ramelteon and 2% with placebo in clinical trials. [3] Side effects leading to discontinuation occurred in 1% or fewer people. [ 3 ] Rarely, anaphylactic reactions , abnormal thinking , and worsening of depression or suicidal thinking in patients with pre-existing depression may occur with ramelteon. [ 3 ]
The popular sleep aid can have side effects.
Zaleplon significantly reduces the time required to fall asleep by improving sleep latency and may therefore facilitate sleep induction rather than sleep maintenance. [ 12 ] [ 13 ] [ 14 ] Due to its ultrashort elimination half-life, zaleplon may not be effective in reducing premature awakenings; however, it may be administered to alleviate ...
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