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Though the exact cause of myxedema is still unclear, a wealth of research has demonstrated the importance of iodine. [10] In an important study [ 11 ] the researchers showed that in the myxedematous type of cretinism treatment with iodine normalizes thyroid function provided that the treatment is begun early in the postnatal period.
However, in 1973, "wrinkly skin syndrome" received its name because of its characterized features of exceedingly wrinkled skin in the hands and feet in a number of related patients. In the same year, WSS was established as a new heritable disorder of connective tissue that appeared to be transmitted as an . [ 16 ]
Wrinkles on the face and hands are a typical sign of aging A wrinkle , also known as a rhytid , is a fold, ridge or crease in an otherwise smooth surface, such as on skin or fabric . Skin wrinkles typically appear as a result of ageing processes such as glycation , [ 1 ] habitual sleeping positions, [ 2 ] loss of body mass, sun damage, [ 3 ] or ...
Common Wrinkles Appearing on the Face. Dynamic wrinkles that form in the outer corners of the eyes are often called crow’s feet. The folds between your eyebrows that show up when you furrow your ...
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Pretibial myxedema is almost always preceded by the ocular signs found in Graves' disease. [3] It usually presents itself as a waxy, discolored induration of the skin—classically described as having a so-called peau d'orange (orange peel) appearance—on the anterior aspect of the lower legs, spreading to the dorsum of the feet, or as a non-localised, non-pitting edema of the skin in the ...
The TSHr is expressed on the thyroid follicular cells of the thyroid gland (the cells that produce thyroid hormone), and the result of chronic stimulation is an abnormally high production of T3 and T4. This, in turn, causes the clinical symptoms of hyperthyroidism, and the enlargement of the thyroid gland visible as goiter.
The most common type of hyperthyroidism, Graves' disease, may additionally cause eye problems (Graves' ophthalmopathy) and skin changes of the legs (pretibial myxedema). [6] Thyroid disease may also cause muscle weakness in the form of thyrotoxic myopathy, but this is constant rather than episodic. [5]