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N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene. [5] METTL3 is located on the human chromosome 14q11.2 (Cancer Biology) and out of the METTL protein family, it is the most studied. [6] This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase.
15107 Ensembl ENSG00000138796 ENSMUSG00000027984 UniProt Q16836 Q61425 RefSeq (mRNA) NM_001184705 NM_005327 NM_001331027 NM_008212 RefSeq (protein) NP_001171634 NP_001317956 NP_005318 NP_032238 Location (UCSC) Chr 4: 107.99 – 108.04 Mb Chr 3: 131.03 – 131.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Hydroxyacyl-Coenzyme A dehydrogenase (HADH) is an enzyme which in humans is ...
The Early 35 kDa protein, or P35 in short, is a baculoviral protein that inhibits apoptosis in the cells infected by the virus. Although baculoviruses infect only invertebrates in nature, ectopic expression of P35 in vertebrate animals and cells also results in inhibition of apoptosis, thus indicating a universal mechanism.
Protein A is a 42 kDa surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins ...
The average size of a protein increases from Archaea to Bacteria to Eukaryote (283, 311, 438 residues and 31, 34, 49 kDa respectively) due to a bigger number of protein domains constituting proteins in higher organisms. [48] For instance, yeast proteins are on average 466 amino acids long and 53 kDa in mass. [39]
Cre recombinase is a widely used tool in the field of molecular biology. The enzyme's unique and specific recombination system is exploited to manipulate genes and chromosomes in a huge range of research, such as gene knock out or knock in studies. The enzyme's ability to operate efficiently in a wide range of cellular environments (including ...
In molecular biology, the mass of macromolecules is referred to as their molecular weight and is expressed in kDa, although the numerical value is often approximate and representative of an average. The terms "molecular mass", "molecular weight", and "molar mass" may be used interchangeably in less formal contexts where unit- and quantity ...
Glutamate cysteine ligase catalytic subunit (GCLC, ~73 kDa) possesses all of substrate and cofactor binding sites and is responsible for all of the catalysis. Glutamate cysteine ligase modifier subunit ( GCLM , ~31 kDa) has no enzymatic activity on its own but increases the catalytic efficiency of GCLC when complexed in the holoenzyme.