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An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.
Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme that is activated by thrombin into activated protein C (APC). Protein C is activated in a sequence that starts with Protein C and thrombin binding to a cell surface protein thrombomodulin. Thrombomodulin binds these proteins in such a way that ...
[3] [4] Heparin is a blood anticoagulant that increases the activity of antithrombin. [5] It is used in the treatment of heart attacks and unstable angina. [3] It can be given intravenously or by injection under the skin. [3] Its anticoagulant properties make it useful to prevent blood clotting in blood specimen test tubes and kidney dialysis ...
Protein C's anticoagulant role in the human body was first noted by Seegers et al. in 1960, [13] who gave protein C its original name, autoprothrombin II-a. [5]: 6822 Protein C was first isolated by Johan Stenflo from bovine plasma in 1976, and Stenflo determined it to be a vitamin K-dependent protein. [14]
Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 464-amino-acid protein produced by the liver.It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasma and has an oligosaccharide occupying each of its four glycosylation sites.
Other eukaryotic chromosomes, i.e., mitochondrial and plasmid-like small chromosomes, are much more variable in number, and there may be thousands of copies per cell. The 23 human chromosome territories during prometaphase in fibroblast cells. Asexually reproducing species have one set of chromosomes that are the same in all body cells. However ...
The combined surface area of all red blood cells of the human body would be roughly 2,000 times as great as the body's exterior surface. [ 14 ] 4,000–11,000 leukocytes : [ 15 ] White blood cells are part of the body's immune system ; they destroy and remove old or aberrant cells and cellular debris, as well as attack infectious agents ...
7056 21824 Ensembl ENSG00000178726 ENSMUSG00000074743 UniProt P07204 P15306 RefSeq (mRNA) NM_000361 NM_009378 RefSeq (protein) NP_000352 NP_033404 Location (UCSC) Chr 20: 23.05 – 23.05 Mb Chr 2: 148.25 – 148.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thrombomodulin (TM), CD 141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and ...