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Exosomes have also been shown to carry double-stranded DNA. [25] Exosomes can transfer molecules from one cell to another via membrane vesicle trafficking, thereby influencing the immune system, such as dendritic cells and B cells, and may play a functional role in mediating adaptive immune responses to pathogens and tumors.
The exosome complex (or PM/Scl complex, often just called the exosome) is a multi-protein intracellular complex capable of degrading various types of RNA (ribonucleic acid) molecules. Exosome complexes are found in both eukaryotic cells and archaea , while in bacteria a simpler complex called the degradosome carries out similar functions.
Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene. [ 5 ] [ 6 ] [ 7 ] This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex , which mediates mRNA degradation.
Exosomes are formed by invagination within a cell to create an intracellular vesicle called an endosome, or an endocytic vesicle. In general, exosomes are formed by segregating the cargo (e.g., lipids, proteins, and nucleic acids) within the endosome. Once formed, the endosome combines with a structure known as a multivesicular body (MVB). The ...
3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene. [5] [6] [7]This gene encodes a core component of the exosome complex.The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening.
227715 Ensembl ENSG00000130713 ENSMUSG00000039356 UniProt Q13868 Q8VBV3 RefSeq (mRNA) NM_001282708 NM_001282709 NM_014285 NM_144886 RefSeq (protein) NP_001269637 NP_001269638 NP_055100 NP_659135 Location (UCSC) Chr 9: 130.69 – 130.71 Mb Chr 2: 31.56 – 31.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Exosome component 2, also known as EXOSC2, is a protein which in humans is ...
Exosome may refer to: Exosome complex , an intracellular macromolecular protein complex involved in RNA degradation Exosome (vesicle) , an extracellular vesicle released from the endosomal compartment of eukaryotic cells
69639 Ensembl ENSG00000120699 ENSMUSG00000027752 UniProt Q96B26 Q9D753 RefSeq (mRNA) NM_181503 NM_001163570 NM_027148 RefSeq (protein) NP_852480 NP_001157042 NP_081424 Location (UCSC) Chr 13: 37 – 37.03 Mb Chr 3: 54.64 – 54.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the ...