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CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis. CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia). [5]
a membrane protein present on many hemopoietic cells and fibroblasts that acts as a ligand for CD2 and may be involved in T-cell function. CD59: Membrane attack complex inhibition factor (MACIF); MAC-inhibitory protein (MAC-IP); Antigen MEM43; Protectin: Immune system complement cascade regulatory factor; Homologous restriction factor(HRF ...
CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. [5] CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex [6] and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. [7] It also is a marker of cells from the monocyte/macrophage lineage. [8]
Schematic representation of the different types of interaction between monotopic membrane proteins and the cell membrane: 1. interaction by an amphipathic α-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ...
All three known members of the selectin family (L-, E-, and P-selectin) share a similar cassette structure: an N-terminal, calcium-dependent lectin domain, an epidermal growth factor (EGF)-like domain, a variable number of consensus repeat units (2, 6, and 9 for L-, E-, and P-selectin, respectively), a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto).
The gene encoding CD69 is located in the NK gene complex on chromosome 6 and chromosome 12 in mice and humans respectively. [7] Activation signaling pathways in lymphocytes, NK cells, dendritic cells and other cell types upregulate transcription factors, such as NF-κB, ERG-1 (erythroblast transformation-specific related gene-1), and AP-1 (activator protein), in order to promote the ...
n/a Ensembl ENSG00000268500 n/a UniProt O15389 n/a RefSeq (mRNA) NM_003830 NM_001384708 NM_001384709 n/a RefSeq (protein) NP_003821 n/a Location (UCSC) Chr 19: 51.61 – 51.63 Mb n/a PubMed search n/a Wikidata View/Edit Human Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. SIGLEC5 has also been designated CD170 (cluster of differentiation 170 ...
Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene. [ 5 ] [ 6 ] [ 7 ] SIRPB1 has also recently been designated CD172B ( cluster of differentiation 172B). The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily.