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The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure [ 1 ] that acts as a binding site for the Tat protein , and this interaction stimulates the activity of the long terminal repeat promoter.
Six human trace amine-associated receptors (hTAARs) – hTAAR1, hTAAR2, hTAAR5, hTAAR6, hTAAR8, and hTAAR9 – have been identified and partially characterized. The table below contains summary information from literature reviews, pharmacology databases, and supplementary primary research articles on the expression profiles, signal transduction mechanisms, ligands, and physiological functions ...
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TDP-43 is 414 amino acid residues long. It consists of four domains: an N-terminal domain spanning residues 1–76 (NTD) with a well-defined fold that has been shown to form a dimer or oligomer; [6] [7] two highly conserved folded RNA recognition motifs spanning residues 106–176 (RRM1) and 191–259 (RRM2), respectively, required to bind target RNA and DNA; [8] an unstructured C-terminal ...
[7] [8] Tat acts by binding to an RNA stem-loop structure, the trans-activation response element (TAR), found at the 5′ ends of nascent HIV-1 transcripts. In binding to TAR, Tat alters the properties of the transcription complex, recruits the positive transcription elongation complex ( P-TEFb ) of cellular CDK9 and cyclin T1 , and hence ...
The IPCC Third Assessment Report (TAR), Climate Change 2001, is an assessment of available scientific and socio-economic information on climate change by the IPCC. Statements of the IPCC or information from the TAR were often used as a reference showing a scientific consensus on the subject of global warming .
One can produce a tar-like substance from corn stalks by heating them in a microwave oven. This process is known as pyrolysis. Tar is a dark brown or black viscous liquid of hydrocarbons and free carbon, obtained from a wide variety of organic materials through destructive distillation. Tar can be produced from coal, wood, petroleum, or peat. [1]
Pitch produced from petroleum may be called bitumen or asphalt, while plant-derived pitch, a resin, is known as rosin in its solid form. Tar is sometimes used interchangeably with pitch, but generally refers to a more liquid substance derived from coal production, including coal tar , or from plants, as in pine tar .
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