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Doses of hydroxyzine hydrochloride used for sleep range from 25 to 100 mg. [15] [16] [17] As with other antihistamine sleep aids, hydroxyzine is usually only prescribed for short term or "as-needed" use since tolerance to the CNS (central nervous system) effects of hydroxyzine can develop in as little as a few days.
Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, either for pleasure or for some other casual purpose or pastime. [1] When a psychoactive drug enters the user's body, it induces an intoxicating effect . [ 1 ]
The other group comprises those that are metabolized through glucuronidation, such as lorazepam, oxazepam, and temazepam, and, in general, have few drug interactions. [ 88 ] Many drugs, including oral contraceptives , some antibiotics , antidepressants , and antifungal agents, inhibit cytochrome enzymes in the liver.
The term PnP is commonly used by gay men [94] [failed verification] and other men who have sex with men (MSM) in North America, while chemsex is more associated with the gay scene in Europe. [95] The drug of choice is typically methamphetamine , known as tina or T, [ 96 ] but other drugs are also used, such as mephedrone , GHB , GBL [ 97 ] and ...
In addition to the added potency, the drug has a “low cost,” which leads drug dealers to mix fentanyl with drugs like “heroin, methamphetamine and cocaine, increasing the likelihood of a ...
An H 3 receptor antagonist is a type of antihistaminic drug used to block the action of histamine at H 3 receptors.. Unlike the H 1 and H 2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H 3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of ...
Brallobarbital was primarily sold as part of a combination product called Vesparax, composed of 150 mg secobarbital, 50 mg brallobarbital and 50 mg hydroxyzine. [2] The long half-life of this combination of drugs tended to cause a hangover effect the next day, [ 3 ] and Vesparax fell into disuse once newer drugs with lesser side effects had ...
Hydroxyzine doesn't act on u-opioid receptors, and the vast majority of anecdotal subjective information (pretty much the only avaliable information on how recreational drugs feel) indicates that hydroxyzine is not "fun" and does not feel like an opiate or even a GABA agonist (benzodiazepine, barbituate, ethanol, meprobamate, carisoprodol, etc ...