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Over-supplementation of vitamins A and D can cause vitamin toxicity in dogs. [72] Excess vitamin A can cause dehydration , joint pain and can also harm the blood vessels , while too much vitamin D can cause muscular atrophy , loss of appetite and many other health-related problems .
Senior dogs require a larger amount of riboflavin for maintenance compared to adult dogs. Vitamin B2, also known as riboflavin, plays an important role as a cofactor for the metabolism of carbohydrates. Riboflavin is required in the diet to prevent cracking and dry skin, as well as a darkening of the pigmentation of skin. [29]
Joint and bone health is an important factor to be considered when purchasing a senior dog food. The addition of glucosamine and chondroitin sulfate has been shown to improve cartilage formation, the composition of synovial fluid , as well as improve signs of osteoarthritis. [ 65 ]
Related: Kennel Cough Symptoms and Ways to Help Your Dog Stay Comfortable. Joint Abnormalities. Patellar luxations, or knees that slip out of place when touched, are usually identified during the ...
Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
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