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Lipoproteins released from treatment of Treponema pallidum infections are believed to induce the Jarisch–Herxheimer reaction. [3] The Herxheimer reaction has shown an increase in inflammatory cytokines during the period of exacerbation, including tumor necrosis factor alpha , interleukin-6 and interleukin-8 .
Adolf Jarisch (February 15, 1850 – March 21, 1902) was an dermatologist from the Austro-Hungarian Empire who specialized in the care of venereal disease.The Jarisch-Herxheimer reaction, an inflammatory response that he noted following treatment for syphilis, is partially named after him.
[135] [138] Adverse reactions to intravenous bacteriophage therapy may include hypotension, i.e., a drop in blood pressure, leading to loss of consciousness. [135] [139] A sudden drop and rise in body temperature, known as the Jarisch–Herxheimer reaction, can occur due to the rapid lysis of bacteria and release of endotoxins. [140]
The exact role of Mycoplasma hominis (and to a lesser extent Ureaplasma) in regards to a number of conditions related to pregnant women and their (unborn) offspring is controversial. This is mainly because many healthy adults have genitourinary colonization with Mycoplasma, published studies on pathogenicity have important design limitations ...
The Jarisch-Herxheimer reaction, which is the response to the body after endotoxins are released by the death of harmful organisms in the human body, starts usually during the first day of antibiotic treatment. [16] The reaction increases the person's body temperature, decreases the overall blood pressure (both systolic and diastolic levels ...
Karl Herxheimer (German pronunciation: [kaʁl ˈhɛʁksˌhaɪmɐ]; 26 June 1861 – 6 December 1942) was a German-Jewish dermatologist who was a native of Wiesbaden. He studied medicine at the universities of Freiburg , Strasbourg and Würzburg , receiving his doctorate in 1885 with a thesis on cerebral syphilis.
Systemic or local inflammatory responses may occur with improvement in immune function. While this inflammatory reaction is usually self-limited, there is risk of long-term symptoms and death, particularly when the central nervous system is involved. [3] [4] Management generally involves symptom control and treatment of the underlying infection.
Mycoplasma species are often found in research laboratories as contaminants in cell culture. Mycoplasmal cell culture contamination occurs due to contamination from individuals or contaminated cell culture medium ingredients. [34] Mycoplasma cells are physically small – less than 1 μm, so are difficult to detect with a conventional microscope.