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Fibromyalgia (FM) is a medical syndrome that causes chronic widespread pain, accompanied by fatigue, awakening unrefreshed, and cognitive symptoms.Other symptoms can include headaches, lower abdominal pain or cramps, and depression. [9]
Biopsy continues to present inconveniences: 30% of patients complain of pain, up to 3% have been noted to have complications severe enough to require hospitalization [14] [15] and a 0.01-0.3% rate of deaths has been reported. [16] [17] [18] There is a mean discordance of 25% between FibroTest and biopsy.
Sensory overload, [13] emotional distress, injury, sleep deprivation, infections, and spending too long standing or sitting up are other potential triggers. [6] The resulting symptoms are disproportionate to the triggering activity and are often debilitating, potentially rendering someone housebound or bedbound until they recover.
Nociplastic pain is a longterm complex pain, one of three mechanisms of pain, defined by the International Association for the Study of Pain as "pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain". [2]
Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective tissue ...
In addition, SLE can flare up during pregnancy, and proper treatment can maintain the health of the mother longer. Women pregnant and known to have anti-Ro (SSA) or anti-La antibodies (SSB) often have echocardiograms during the 16th and 30th weeks of pregnancy to monitor the health of the heart and surrounding vasculature. [138]
Tests for rheumatoid factor and anti-nuclear antibodies are usually negative and serum ferritin is markedly elevated. Patients experiencing a flare-up from adult-onset Still's disease usually report extreme fatigue, swelling of the lymph nodes and, less commonly, fluid accumulation in the lungs and heart.
The malignant ameloblastic fibroma will have features of malignant transformation such as mitotic figures in either epithelial or mesenchymal tissue. [8] There is a resemblance to fibrosarcoma. The malignant Ameloblastic Fibroma histologically shows transformation in the mesenchymal component with increased cellularity, accompanied by a ...