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In what the university calls the largest study of its kind, researchers used brain imaging technology to explore the effects of recent and lifetime cannabis use on brain function among more than ...
“The cannabinoid system is widespread in the brain, so modulating cannabinoid function with products like THC could have a wide range of possible effects. We wanted to better understand which ...
While the most likely cellular targets and executors of the CB 2 receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells (e.g. leukocytes, various populations of T and B lymphocytes, monocytes/macrophages, dendritic cells, mast cells, microglia in the brain, Kupffer cells in the liver ...
3D model of 2-Arachidonoylglycerol, an endocannaboid. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central nervous system (including the brain) and peripheral nervous system.
The psychoactive effects of cannabis, known as a "high", are subjective and vary among persons and the method of use. When THC enters the blood stream and reaches the brain, it binds to cannabinoid receptors. The endogenous ligand of these receptors is anandamide, the effects of which THC emulates.
A growing body of research and numerous anecdotal reports link cannabis with several health benefits.
Cnr1 is widely expressed in all major regions of the postnatal day 14 mouse brain, but is conspicuously absent in much of the thalamus. CB1 receptors are expressed most densely in the central nervous system and are largely responsible for mediating the effects of cannabinoid binding in the brain.
D’Souza added that cannabis use can have serious impacts on the developing brain because of its effects on the endocannabinoid system, a complex signaling system in the brain that marijuana targets.