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The loop has also been divided into limbic, associative, oculomotor, and motor circuits [4] to explain the role of dopamine in the basal ganglia on motivational states. [10] A five loop division based on primary cortical targets has been described as follows: [11]
Cortico-basal ganglia-thalamo-cortical loop [ edit ] The dopaminergic pathways that project from the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) into the striatum (i.e., the nigrostriatal and mesolimbic pathways, respectively) form one component of a sequence of pathways known as the cortico-basal ganglia-thalamo ...
The limbic loop is a functional pathway of the basal ganglia, in which the ventral pallidum is involved. It (and the internal globus pallidus and substantia nigra pars reticulata) receives input from the temporal lobes, and the hippocampus via the ventral striatum.
The limbic system also interacts with the basal ganglia. The basal ganglia are a set of subcortical structures that direct intentional movements. The basal ganglia are located near the thalamus and hypothalamus. They receive input from the cerebral cortex, which sends outputs to the motor centers in the brain stem. A part of the basal ganglia ...
The mesolimbic pathway and its positioning in relation to the other dopaminergic pathways. The mesolimbic pathway is a collection of dopaminergic (i.e., dopamine-releasing) neurons that project from the ventral tegmental area (VTA) to the ventral striatum, which includes the nucleus accumbens (NAcc) and olfactory tubercle. [9]
Within the basal ganglia, there are several complex circuits of neuronal loops all of which include medium spiny neurons. The cortical, thalamic, and brain-stem inputs that arrive at the medium spiny neurons show a vast divergence in that each incoming axon forms contacts with many spiny neurons and each spiny neuron receives a vast amount of ...
The striatum (pl.: striata) or corpus striatum [5] is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. [6] The striatum is a critical component of the motor and reward systems; receives glutamatergic and dopaminergic inputs from different sources; and serves as the primary input to the rest of the basal ganglia.
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.